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Pharmacodynamics and pharmacokinetics in humans Phase 0 trials are optional first-in-human trials. Single subtherapeutic doses of the study drug or treatment are given to a small number of subjects 10 to 15 to gather preliminary data on the agent's pharmacodynamics what the drug does to the body and pharmacokinetics what the body does to the drugs.

Case study open view

They are used in the selection of leader and in the determination of issue. This conception implies that voters are presented with alternatives that they can choose among a number of proposals designed to settle an Case study open view of public concern.

Elections are central to the existence stability and development of democracy. Given the distortions received in Nigeria, it is important to understand what the word Election means. The encyclopedia of social science defines election. The process of selecting the officers or representative of an organisation or from by the vote of its qualified members.

Election could be defined in a technical sense as the process by which an office is assigned to a person by an act of voting needing the simultaneous expression of opinion by many people.

In a social sense Election is the process by which a person is liked to an office with due provision for the participation of the people meant to come under the officer is authority. Accordingly, it is observed that this social aspect of election give the idea of ruling a society with the consent of the ruled, which tantamount to democracy and differentiates it from appointment.

Case study open view

An election is meant to given the electorates the opportunity to decide who should rule them, and what the rulers polices and programmes should be. The commission decision meant the president the members of the house of Representative and that of the senate would come to power from the new breed political parties in It should be observed here that, it was the same faces and names that were once again entering the political area.

On December 28,the leaders of the Nigeria five new political parties issued a S. The leaders pledged that they leadership to the country but that also curb excesses in speech and behaviour by their party members.

They would restrain their members from engaging in political thuggery and ensure that nothing was done to disturb the peace of the community or upset the Unity of the country. Above all, they would accept the verdict of the electorate in the elections which they would help to make peaceful, Free and fair.

The presidency was help out as the biggest price in the series of elections in Nigeria. This was because the constitution was specific in providing that the president should be the head of state. The chief executive of the federal and also the commander-in-chief of the armed force.

By the nature of role, the president performs also the functions of the chief Diplomat the chief legislator and the chief Administrator. All these constituted an enormous power to be bestowed on a single individual, and no double cities have shouted at the possibility of the constitution inadvertently creating a dictator to run a democratic office.

And no wonder why the presidential election was fought with funny. Polled a total of 5, voted to beat out rightly his four opponent president Shahu Shagiri. Government was topped in a caup atat on 31st December, by the then head of state and commander-in-chief of the Nigeria armed forces.

On his assumption of office General Muhammadu Buhari announced his intention to hand overpower to an elected civilian administration come The Babangida administration which ousted Buhari government on August 29, charged the data for the return to civil rule from to It has become a tradition amongst new military administration to announce or embark on new transition to civil rule programme on assumption of office.

Babangida, after displacing General Buhari from office on August 27, announced his own transition to civil rule programme, which will return power to civilian ininstead of as was announced by General Buhari during his our Broadcast to the nation.

Following the creation of two national political parties.

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Although before Elections were conducted on March 26, In some head government yet the generally of the people felt that the Electoral process has been distorted. This created room for doubt on the credibility of National Electoral commission NEC instituted as a body to see to the smooth transition to democratic government.

The generally of the people began to wonder on what might be outcome of other subsequent elections in Nigeria.

According to many political observers, democracy has suffered many set backs in Nigeria due to the farness of those who are ready and willing to defend it.

This is why every electoral commission set up in Nigeria to see to the achievement of lasting democracy in Nigeria has failed. In the front Republic the electoral commission under the chairmanship of Dr. Esau failed to achieve the purpose for which it was set up.

In the second republic, another electoral commission was setup under the chairmanship of Ovie Whisky, and the commission could not also achieve desired result.Case Western Reserve University: the top-ranked private research university in Ohio and one of the best in the U.S.

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